ConditionPopulationRole RegionSetting Condition Population Role Region Site Diagnostic Reasoning for Any Presenting Complaint Initial Assessment Questions What is the epidemiology and prevalence of in adult presenting to primary care in UK? What are the validated pre-test probability scores and decision rules for assessing in adult? What is the diagnostic approach that a clinician should take when assessing in primary care? Differential Diagnosis Questions Provide a comprehensive DDx for in adult patients presenting to primary care What are the most common causes of in adult presenting to primary care, ranked by frequency with likelihood ratios? What are the 'must-not-miss' diagnoses for in adult, and what are their key distinguishing features? Which conditions commonly mimic in adult, and how can a clinician distinguish between them? History Taking Questions What specific questions should a clinician ask when taking a history for in adult, and what are the likelihood ratios for each positive finding? What are the validated red flag symptoms for in adult, and what serious conditions do they indicate? Which symptom combinations have the highest diagnostic value for serious causes of in adult? Physical Examination Questions What are the key physical examination findings for in adult, with their sensitivity, specificity and likelihood ratios? Which physical examination signs have the highest predictive value for serious causes of in adult? What is the evidence-based physical examination sequence for in primary care? Investigation Questions What is the optimal sequence of investigations for in adult presenting to primary care, with pre-test probabilities? What are the sensitivity, specificity, and likelihood ratios of different investigations for in adult? How do investigation results modify pre-test probability in for adult? Risk Assessment Questions What are the validated risk stratification tools for in adult, and how should they guide management? What features of indicate the need for immediate action or referral from primary care? What are the evidence-based criteria for admission vs discharge for in adult presenting to primary care? Special Circumstances Questions How does the diagnostic approach to need to be modified for adult with [comorbidity]? What are the key diagnostic considerations for in adult during pregnancy? How should the diagnostic approach to be adjusted in resource-limited primary care? Documentation Questions What are the essential elements to document when assessing in adult presenting to primary care? How should diagnostic uncertainty be documented when assessing in primary care? What are the medico-legal considerations when documenting assessment of in primary care? Learning Points Questions What are the key cognitive biases that affect diagnosis of in primary care? What are the common diagnostic pitfalls when assessing in adult? What are the latest evidence-based updates in diagnosis of that a clinician should know?